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Involvement of HMGB1 mediated signalling pathway in diabetic retinopathy: evidence from type 2 diabetic rats and ARPE-19 cells under diabetic condition.
|Title||Involvement of HMGB1 mediated signalling pathway in diabetic retinopathy: evidence from type 2 diabetic rats and ARPE-19 cells under diabetic condition.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Chen X-L, Zhang X-D, Li Y-Y, Chen X-M, Tang D-R, Ran R-J|
|Journal||The British journal of ophthalmology|
|Date Published||2013 Dec|
Inflammation is considered to play a critical role in the pathogenesis of diabetic retinopathy, and high mobility group box protein 1 (HMGB1) could promote inflammation as an alarmin. We investigated the expression of HMGB1 signalling pathway components in type 2 diabetic rat retinas and in high glucose cultured ARPE-19 cells.
|Alternate Journal||Br J Ophthalmol|