Involvement of HMGB1 mediated signalling pathway in diabetic retinopathy: evidence from type 2 diabetic rats and ARPE-19 cells under diabetic condition.

TitleInvolvement of HMGB1 mediated signalling pathway in diabetic retinopathy: evidence from type 2 diabetic rats and ARPE-19 cells under diabetic condition.
Publication TypeJournal Article
Year of Publication2013
AuthorsChen X-L, Zhang X-D, Li Y-Y, Chen X-M, Tang D-R, Ran R-J
JournalThe British journal of ophthalmology
Volume97
Issue12
Pagination1598-603
Date Published2013 Dec
Abstract

Inflammation is considered to play a critical role in the pathogenesis of diabetic retinopathy, and high mobility group box protein 1 (HMGB1) could promote inflammation as an alarmin. We investigated the expression of HMGB1 signalling pathway components in type 2 diabetic rat retinas and in high glucose cultured ARPE-19 cells.

DOI10.3969/j.issn.1671-5411.2013.03.001
Alternate JournalBr J Ophthalmol