The Integrated Web Portal for Escalation with Overdose Control (EWOC).

TitleThe Integrated Web Portal for Escalation with Overdose Control (EWOC).
Publication TypeJournal Article
Year of Publication2013
AuthorsWang H, Tighiouart M, Huang S-C, Berel D, Cook-Wiens G, Bresee C, Li Q, Rogatko A
JournalThe open medical informatics journal
Date Published2013

In this paper, we present the design and implementation of a novel web portal for the cancer phase I clinical trial design method Escalation with Overdose Control (EWOC). The web portal has two major components: a web-based dose finding calculator; and a standalone and downloadable dose finding software which can be installed on Windows operating systems. The web-based dose finding calculator uses industry standards and is a database-driven and distributed computing platform for designing and conducting dose finding in cancer phase I clinical trials utilizing EWOC methodology. The web portal is developed using open source software: PHP, JQuery, R and OpenBUGS. It supports any standard browsers with internet connection. The web portal can be accessed at:

Alternate JournalOpen Med Inform J