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The Integrated Web Portal for Escalation with Overdose Control (EWOC).
|Title||The Integrated Web Portal for Escalation with Overdose Control (EWOC).|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Wang H, Tighiouart M, Huang S-C, Berel D, Cook-Wiens G, Bresee C, Li Q, Rogatko A|
|Journal||The open medical informatics journal|
In this paper, we present the design and implementation of a novel web portal for the cancer phase I clinical trial design method Escalation with Overdose Control (EWOC). The web portal has two major components: a web-based dose finding calculator; and a standalone and downloadable dose finding software which can be installed on Windows operating systems. The web-based dose finding calculator uses industry standards and is a database-driven and distributed computing platform for designing and conducting dose finding in cancer phase I clinical trials utilizing EWOC methodology. The web portal is developed using open source software: PHP, JQuery, R and OpenBUGS. It supports any standard browsers with internet connection. The web portal can be accessed at: http://biostatistics.csmc.edu.
|Alternate Journal||Open Med Inform J|