Inhibitory effect of IL-17 on neural stem cell proliferation and neural cell differentiation.

TitleInhibitory effect of IL-17 on neural stem cell proliferation and neural cell differentiation.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi Z, Li K, Zhu L, Kan Q, Yan Y, Kumar P, Xu H, Rostami A, Zhang G-X
JournalBMC immunology
Volume14
Pagination20
Date Published2013
Abstract

IL-17, a Th17 cell-derived proinflammatory molecule, has been found to play an important role in the pathogenesis of autoimmune diseases, including multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). While IL-17 receptor (IL-17R) is expressed in many immune-related cells, microglia, and astrocytes, it is not known whether IL-17 exerts a direct effect on neural stem cells (NSCs) and oligodendrocytes, thus inducing inflammatory demyelination in the central nervous system.

DOI10.1039/c3an01929b
Alternate JournalBMC Immunol.