Inhibition of BCR/ABL protein expression by miR-203 sensitizes for imatinib mesylate.

TitleInhibition of BCR/ABL protein expression by miR-203 sensitizes for imatinib mesylate.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi Y, Yuan Y, Tao K, Wang X, Xiao Q, Huang Z, Zhong L, Cao W, Wen J, Feng W
JournalPloS one
Volume8
Issue4
Paginatione61858
Date Published2013
Abstract

Selective inhibition of BCR/ABL expression by RNA interference has been demonstrated as an effective strategy in CML treatment and a reversal to imatinib resistance. microRNAs (miRNAs) are small regulatory RNAs involved in post-transcriptional gene regulation. miR-203 is supposed to directly regulate ABL and BCR/ABL expression, however, the role of miR-203 in imatinib-resistant cells is not clear. Here, we report that overexpression of miR-203 in BaF3-BCR/ABL cells with T315I mutant inhibited cell growth and colony formation ability. Furthermore, miR-203 increased sensitivity to imatinib in BaF3-BCR/ABL(T315I) cells, thereby antagonizing the main mechanism of resistance to imatinib.

DOI10.1242/bio.20133988
Alternate JournalPLoS ONE