The influence of exposure to maternal diabetes in utero on the rate of decline in β-cell function among youth with diabetes.

TitleThe influence of exposure to maternal diabetes in utero on the rate of decline in β-cell function among youth with diabetes.
Publication TypeJournal Article
Year of Publication2013
AuthorsCrume TL, Andrews JS, D'Agostino RB, Pettitt DJ, Mayer-Davis EJ, Law JR, Dolan L, Lawrence JM, Saydah S, Greenbaum C, Rodriguez BL, Dabelea D
Corporate AuthorsSEARCH for Diabetes in Youth Study Group
JournalJournal of pediatric endocrinology & metabolism : JPEM
Volume26
Issue7-8
Pagination721-7
Date Published2013
Abstract

Abstract We explored the influence of exposure to maternal diabetes in utero on β cell decline measured by fasting C-peptide (FCP) among 1079 youth <20 years with diabetes, including 941 with type 1 and 138 with type 2 diabetes. Youths exposed to maternal diabetes had FCP levels that were 17% lower among youth with type 2 diabetes [95% confidence interval (CI): -34%, +6%] and 15% higher among youth with type 1 diabetes (95%CI: -14%, +55%) than their unexposed counterparts, although differences were not statistically significant (p=0.13 and p=0.35, respectively). Exposure to maternal diabetes was not associated with FCP decline in youth with type 2 (p=0.16) or type 1 diabetes (p=0.90); nor was the effect of in utero exposure on FCP modified by diabetes type. Findings suggest that exposure to maternal diabetes in utero may not be an important determinant of short-term β-cell function decline in youth with type 1 or type 2 diabetes.

DOI10.1111/1744-7917.12057
Alternate JournalJ. Pediatr. Endocrinol. Metab.