Increased risk for congenital heart defects in children carrying the ABCB1 Gene C3435T polymorphism and maternal periconceptional toxicants exposure.

TitleIncreased risk for congenital heart defects in children carrying the ABCB1 Gene C3435T polymorphism and maternal periconceptional toxicants exposure.
Publication TypeJournal Article
Year of Publication2013
AuthorsWang C, Xie L, Zhou K, Zhan Y, Li Y, Li H, Qiao L, Wang F, Hua Y
JournalPloS one
Volume8
Issue7
Paginatione68807
Date Published2013
Abstract

The etiology of congenital heart defect (CHD) is commonly believed to involve the interaction of multiple environmental and genetic factors. This study aimed to explore the joint effects of the ABCB1 gene C3435T polymorphism and maternal periconceptional toxicants exposure on the CHD risk in a Han Chinese population.

DOI10.1371/journal.pone.0069942
Alternate JournalPLoS ONE