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Impact of high glucose and proteasome inhibitor MG132 on histone H2A and H2B ubiquitination in rat glomerular mesangial cells.
|Title||Impact of high glucose and proteasome inhibitor MG132 on histone H2A and H2B ubiquitination in rat glomerular mesangial cells.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Gao C, Chen G, Liu L, Li X, He J, Jiang L, Zhu J, Xu Y|
|Journal||Journal of diabetes research|
Hyperglycemia plays a pivotal role in the development of diabetic nephropathy (DN) and may be related to epigenetic metabolic memory. One of the most crucial epigenetic mechanisms is histone modification, which is associated with the expression of a fibrosis factor in vascular injury. Aim .In this study, we investigated the ubiquitination of histones H2A and H2B to explore the epigenetic mechanisms of DN.
|Alternate Journal||J Diabetes Res|