Impact of high glucose and proteasome inhibitor MG132 on histone H2A and H2B ubiquitination in rat glomerular mesangial cells.

TitleImpact of high glucose and proteasome inhibitor MG132 on histone H2A and H2B ubiquitination in rat glomerular mesangial cells.
Publication TypeJournal Article
Year of Publication2013
AuthorsGao C, Chen G, Liu L, Li X, He J, Jiang L, Zhu J, Xu Y
JournalJournal of diabetes research
Volume2013
Pagination589474
Date Published2013
Abstract

Hyperglycemia plays a pivotal role in the development of diabetic nephropathy (DN) and may be related to epigenetic metabolic memory. One of the most crucial epigenetic mechanisms is histone modification, which is associated with the expression of a fibrosis factor in vascular injury. Aim .In this study, we investigated the ubiquitination of histones H2A and H2B to explore the epigenetic mechanisms of DN.

DOI10.1155/2013/589474
Alternate JournalJ Diabetes Res