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Illuminating regeneration: noninvasive imaging of disease progression in muscular dystrophy.
|Title||Illuminating regeneration: noninvasive imaging of disease progression in muscular dystrophy.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Levy JR, Campbell KP|
|Journal||The Journal of clinical investigation|
|Date Published||2013 May 1|
Muscular dystrophies are characterized by progressive muscle weakness and wasting. Among the key obstacles to the development of therapies is the absence of an assay to monitor disease progression in live animals. In this issue of the JCI, Maguire and colleagues use noninvasive bioluminescence imaging to monitor luciferase activity in mice expressing an inducible luciferase reporter gene in satellite cells. These cells proliferate in response to degeneration, therefore increasing the level of luciferase expression in dystrophic muscle.
|Alternate Journal||J. Clin. Invest.|