Illuminating regeneration: noninvasive imaging of disease progression in muscular dystrophy.

TitleIlluminating regeneration: noninvasive imaging of disease progression in muscular dystrophy.
Publication TypeJournal Article
Year of Publication2013
AuthorsLevy JR, Campbell KP
JournalThe Journal of clinical investigation
Volume123
Issue5
Pagination1931-4
Date Published2013 May 1
Abstract

Muscular dystrophies are characterized by progressive muscle weakness and wasting. Among the key obstacles to the development of therapies is the absence of an assay to monitor disease progression in live animals. In this issue of the JCI, Maguire and colleagues use noninvasive bioluminescence imaging to monitor luciferase activity in mice expressing an inducible luciferase reporter gene in satellite cells. These cells proliferate in response to degeneration, therefore increasing the level of luciferase expression in dystrophic muscle.

DOI10.1371/journal.pntd.0002285
Alternate JournalJ. Clin. Invest.