IL-9 and Th9 cells: progress and challenges.

TitleIL-9 and Th9 cells: progress and challenges.
Publication TypeJournal Article
Year of Publication2013
AuthorsZhao P, Xiao X, Ghobrial RM, Li XC
JournalInternational immunology
Volume25
Issue10
Pagination547-51
Date Published2013 Oct
Abstract

T(h)9 cells are a new subset of helper T cells, and the signature cytokine for T(h)9 cells is IL-9. Both T(h)9 cells and T(h)9 products are implicated in multiple disease settings. Thus, a clear understanding of how T(h)9 cells are induced and controlled is an important and clinically relevant issue. There are different molecular pathways identified thus far in the induction of T(h)9 cells, and activation of such diverse pathways requires integration of signals from TGF-β and IL-4 cytokine receptors as well as costimulatory molecules. These signals converge on the induction of multiple transcription factors that collectively drive the development of T(h)9 cells.

DOI10.7717/peerj.132
Alternate JournalInt. Immunol.