Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level.

TitleIdentity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi Y, Sacchi S, Pollegioni L, Basu AC, Coyle JT, Bolshakov VY
JournalNature communications
Volume4
Pagination1760
Date Published2013
Abstract

Mechanisms of N-methyl-D-aspartate receptor-dependent synaptic plasticity contribute to the acquisition and retention of conditioned fear memory. However, synaptic rules which may determine the extent of N-methyl-D-aspartate receptor activation in the amygdala, a key structure implicated in fear learning, remain unknown. Here we show that the identity of the N-methyl-D-aspartate receptor glycine site agonist at synapses in the lateral nucleus of the amygdala may depend on the level of synaptic activation. Tonic activation of N-methyl-D-aspartate receptors at synapses in the amygdala under low activity conditions is supported by ambient D-serine, whereas glycine may be released from astrocytes in response to afferent impulses. The release of glycine may decode the increases in afferent activity levels into enhanced N-methyl-D-aspartate receptor-mediated synaptic events, serving an essential function in the induction of N-methyl-D-aspartate receptor-dependent long-term potentiation in fear conditioning pathways.

DOI10.1155/2013/384125
Alternate JournalNat Commun