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Identification of inhibitors of ovarian cancer stem-like cells by high-throughput screening.
|Title||Identification of inhibitors of ovarian cancer stem-like cells by high-throughput screening.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Mezencev R, Wang L, McDonald JF|
|Journal||Journal of ovarian research|
Ovarian cancer stem cells are characterized by self-renewal capacity, ability to differentiate into distinct lineages, as well as higher invasiveness and resistance to many anticancer agents. Since they may be responsible for the recurrence of ovarian cancer after initial response to chemotherapy, development of new therapies targeting this special cellular subpopulation embedded within bulk ovarian cancers is warranted.
|Alternate Journal||J Ovarian Res|