Identification of gene expression-based prognostic markers in the hematopoietic stem cells of patients with myelodysplastic syndromes.

TitleIdentification of gene expression-based prognostic markers in the hematopoietic stem cells of patients with myelodysplastic syndromes.
Publication TypeJournal Article
Year of Publication2013
AuthorsPellagatti A, Benner A, Mills KI, Cazzola M, Giagounidis A, Perry J, Malcovati L, Della Porta MG, Jädersten M, Verma A, McDonald E-J, Killick S, Hellström-Lindberg E, Bullinger L, Wainscoat JS, Boultwood J
JournalJournal of clinical oncology : official journal of the American Society of Clinical Oncology
Volume31
Issue28
Pagination3557-64
Date Published2013 Oct 1
Abstract

The diagnosis of patients with myelodysplastic syndromes (MDS) is largely dependent on morphologic examination of bone marrow aspirates. Several criteria that form the basis of the classifications and scoring systems most commonly used in clinical practice are affected by operator-dependent variation. To identify standardized molecular markers that would allow prediction of prognosis, we have used gene expression profiling (GEP) data on CD34+ cells from patients with MDS to determine the relationship between gene expression levels and prognosis.

DOI10.1039/c3cp52823e
Alternate JournalJ. Clin. Oncol.