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Identification of gene expression-based prognostic markers in the hematopoietic stem cells of patients with myelodysplastic syndromes.
|Title||Identification of gene expression-based prognostic markers in the hematopoietic stem cells of patients with myelodysplastic syndromes.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Pellagatti A, Benner A, Mills KI, Cazzola M, Giagounidis A, Perry J, Malcovati L, Della Porta MG, Jädersten M, Verma A, McDonald E-J, Killick S, Hellström-Lindberg E, Bullinger L, Wainscoat JS, Boultwood J|
|Journal||Journal of clinical oncology : official journal of the American Society of Clinical Oncology|
|Date Published||2013 Oct 1|
The diagnosis of patients with myelodysplastic syndromes (MDS) is largely dependent on morphologic examination of bone marrow aspirates. Several criteria that form the basis of the classifications and scoring systems most commonly used in clinical practice are affected by operator-dependent variation. To identify standardized molecular markers that would allow prediction of prognosis, we have used gene expression profiling (GEP) data on CD34+ cells from patients with MDS to determine the relationship between gene expression levels and prognosis.
|Alternate Journal||J. Clin. Oncol.|