Human cells display reduced apoptotic function relative to chimpanzee cells.

TitleHuman cells display reduced apoptotic function relative to chimpanzee cells.
Publication TypeJournal Article
Year of Publication2012
AuthorsArora G, Mezencev R, McDonald JF
JournalPloS one
Volume7
Issue9
Paginatione46182
Date Published2012
Abstract

Previously published gene expression analyses suggested that apoptotic function may be reduced in humans relative to chimpanzees and led to the hypothesis that this difference may contribute to the relatively larger size of the human brain and the increased propensity of humans to develop cancer. In this study, we sought to further test the hypothesis that humans maintain a reduced apoptotic function relative to chimpanzees by conducting a series of apoptotic function assays on human, chimpanzee and macaque primary fibroblastic cells. Human cells consistently displayed significantly reduced apoptotic function relative to the chimpanzee and macaque cells. These results are consistent with earlier findings indicating that apoptotic function is reduced in humans relative to chimpanzees.

DOI10.1371/journal.pone.0050430
Alternate JournalPLoS ONE