High-resolution 3D structures reveal the biological functions of reoviruses.

TitleHigh-resolution 3D structures reveal the biological functions of reoviruses.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi X, Fang Q
JournalVirologica Sinica
Volume28
Issue6
Pagination318-25
Date Published2013 Dec
Abstract

Viruses in the family Reoviridae are non-enveloped particles comprising a segmented double-stranded RNA genome surrounded by a two-layered or multi-layered icosahedral protein capsid. These viruses are classified into two sub-families based on their particle structural organization. Recent studies have focused on high-resolution three-dimensional structures of reovirus particles by using cryo-electron microscopy (cryo-EM) to approach the resolutions seen in X-ray crystallographic structures. The results of cryo-EM image reconstructions allow tracing of most of the protein side chains, and thus permit integration of structural and functional information into a coherent mechanism for reovirus assembly and entry.

DOI10.1371/journal.pone.0081420
Alternate JournalVirol Sin