News & Updates
Search Research Content
Resource Finder at Kennedy Krieger Institute
A free resource that provides access to information and support for individuals and families living with developmental disabilities.
High-resolution 3D structures reveal the biological functions of reoviruses.
|Title||High-resolution 3D structures reveal the biological functions of reoviruses.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Li X, Fang Q|
|Date Published||2013 Dec|
Viruses in the family Reoviridae are non-enveloped particles comprising a segmented double-stranded RNA genome surrounded by a two-layered or multi-layered icosahedral protein capsid. These viruses are classified into two sub-families based on their particle structural organization. Recent studies have focused on high-resolution three-dimensional structures of reovirus particles by using cryo-electron microscopy (cryo-EM) to approach the resolutions seen in X-ray crystallographic structures. The results of cryo-EM image reconstructions allow tracing of most of the protein side chains, and thus permit integration of structural and functional information into a coherent mechanism for reovirus assembly and entry.
|Alternate Journal||Virol Sin|