High-dose cyclophosphamide versus monthly intravenous cyclophosphamide for systemic lupus erythematosus: a prospective randomized trial.

TitleHigh-dose cyclophosphamide versus monthly intravenous cyclophosphamide for systemic lupus erythematosus: a prospective randomized trial.
Publication TypeJournal Article
Year of Publication2010
AuthorsPetri M, Brodsky RA, Jones RJ, Gladstone D, Fillius M, Magder LS
JournalArthritis and rheumatism
Volume62
Issue5
Pagination1487-93
Date Published2010 May
Abstract

Monthly intravenous (IV) cyclophosphamide for 6 months has been the standard induction regimen for lupus nephritis, followed by a maintenance regimen of quarterly infusions for 2 years. We undertook this study to compare the efficacy and safety of the standard regimen versus a high-dose IV cyclophosphamide regimen.

DOI10.1177/0883073809350221
Alternate JournalArthritis Rheum.