Hawley H. Seiler Resident Award. Transcriptional profile of brain injury in hypothermic circulatory arrest and cardiopulmonary bypass.

TitleHawley H. Seiler Resident Award. Transcriptional profile of brain injury in hypothermic circulatory arrest and cardiopulmonary bypass.
Publication TypeJournal Article
Year of Publication2010
AuthorsAllen JG, Weiss ES, Wilson MA, Arnaoutakis GJ, Blue ME, Talbot CC, Jie C, Lange MS, Troncoso JC, Johnston MV, Baumgartner WA
JournalThe Annals of thoracic surgery
Volume89
Issue6
Pagination1965-71
Date Published2010 Jun
Abstract

Little is known about the molecular mechanisms of neurologic complications after hypothermic circulatory arrest (HCA) with cardiopulmonary bypass (CPB). Canine genome sequencing allows profiling of genomic changes after HCA and CPB alone. We hypothesize that gene regulation will increase with increased severity of injury.

DOI10.1016/j.neuroimage.2010.06.058
Alternate JournalAnn. Thorac. Surg.