HAb18G/CD147 Promotes pSTAT3-Mediated Pancreatic Cancer Development via CD44s.

TitleHAb18G/CD147 Promotes pSTAT3-Mediated Pancreatic Cancer Development via CD44s.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi L, Tang W, Wu X, Karnak D, Meng X, Thompson R, Hao X, Li Y, Qiao XT, Lin J, Fuchs J, Simeone DM, Chen Z-N, Lawrence TS, Xu L
JournalClinical cancer research : an official journal of the American Association for Cancer Research
Volume19
Issue24
Pagination6703-15
Date Published2013 Dec 15
Abstract

Signal transducer and activator of transcription 3 (STAT3) plays a critical role in initiation and progression of pancreatic cancer. However, therapeutically targeting STAT3 has failed clinically. We previously identified HAb18G/CD147 as an effective target for cancer treatment. In this study, we aimed to investigate the potential role of HAb18G/CD147 in STAT3-involved pancreatic tumorigenesis in vitro and in vivo.

DOI10.3969/j.issn.1671-5411.2013.03.001
Alternate JournalClin. Cancer Res.