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HAb18G/CD147 Promotes pSTAT3-Mediated Pancreatic Cancer Development via CD44s.
|Title||HAb18G/CD147 Promotes pSTAT3-Mediated Pancreatic Cancer Development via CD44s.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Li L, Tang W, Wu X, Karnak D, Meng X, Thompson R, Hao X, Li Y, Qiao XT, Lin J, Fuchs J, Simeone DM, Chen Z-N, Lawrence TS, Xu L|
|Journal||Clinical cancer research : an official journal of the American Association for Cancer Research|
|Date Published||2013 Dec 15|
Signal transducer and activator of transcription 3 (STAT3) plays a critical role in initiation and progression of pancreatic cancer. However, therapeutically targeting STAT3 has failed clinically. We previously identified HAb18G/CD147 as an effective target for cancer treatment. In this study, we aimed to investigate the potential role of HAb18G/CD147 in STAT3-involved pancreatic tumorigenesis in vitro and in vivo.
|Alternate Journal||Clin. Cancer Res.|