Genetic polymorphisms of the CASP8 gene promoter may not be associated with colorectal cancer in Han Chinese from southwest China.

TitleGenetic polymorphisms of the CASP8 gene promoter may not be associated with colorectal cancer in Han Chinese from southwest China.
Publication TypeJournal Article
Year of Publication2013
AuthorsXiao M-S, Chang L, Li W-L, Du Y-S, Pan Y, Zhang D-F, Wen Y, Luo J, Li X-Y, Yao Y-G
JournalPloS one
Volume8
Issue7
Paginatione67577
Date Published2013
Abstract

Caspase 8 (CASP8) plays a critical role in the apoptotic pathway and aberrant regulation of this pathway causes many diseases including cancers. Genetic variants rs3834129 (CTTACT/-) and rs3769821 (T/C) in the promoter region of the CASP8 gene were documented to be associated with multiple solid cancers and non-Hodgkin's lymphoma (NHL), respectively, despite of some controversies. We aimed to discern potential association of these two variants and rs113686495 (CTGTCATT/-), as well as CASP8 mRNA and protein expression levels with colorectal cancer (CRC) in Han Chinese.

DOI10.1371/journal.pone.0068568
Alternate JournalPLoS ONE