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Genetic determinants of high on-treatment platelet reactivity in clopidogrel treated Chinese patients.
|Title||Genetic determinants of high on-treatment platelet reactivity in clopidogrel treated Chinese patients.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Zhang L, Chen Y, Jin Y, Qu F, Li J, Ma C, Yang J, Xu B, Wang H, Li X, Li Y, Zhang Y, Lu C, Yin T|
|Date Published||2013 Jul|
Cytochrome P450 (CYP), ATP-binding cassette transporters (ABCB1), and paraoxonase-1 (PON1) play crucial roles in clopidogel absorption and bioactivation. Genetic polymorphisms in these genes have been associated with the variability of the response to clopidogrel, however their contribution to high on-treatment platelet reactivity (HPR) in clopidogrel treated Chinese patients is less known.
|Alternate Journal||Thromb. Res.|