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Generation of humanized animal livers using embryoid body-derived stem cell transplant.
|Title||Generation of humanized animal livers using embryoid body-derived stem cell transplant.|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Authors||Locke JE, Sun Z, Warren DS, Sheets TP, Holzer H, Shamblott MJ, Montgomery RA, Cameron AM|
|Journal||Annals of surgery|
|Date Published||2008 Sep|
Animal organs engineered to be chimeric for human cells could contribute significantly to the field of transplantation, including studies of human-specific diseases such as hepatitis-C, as treatment for in-born errors of metabolism, and for development of a renewable source of transplantable organs via modified xenotransplantation. We sought to use human embryoid body-derived stem cells (EBDs) to populate livers in animals for applications in transplant surgery.
|Alternate Journal||Ann. Surg.|