Generation of fatty acids from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine/cardiolipin liposomes that stabilize recombinant human serum albumin.

TitleGeneration of fatty acids from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine/cardiolipin liposomes that stabilize recombinant human serum albumin.
Publication TypeJournal Article
Year of Publication2013
AuthorsFrahm GE, Cameron BE, Smith JC, Johnston MJW
JournalJournal of liposome research
Volume23
Issue2
Pagination101-9
Date Published2013 Jun
Abstract

At elevated temperatures, studies have shown that serum albumin undergoes irreversible changes to its secondary structure. Anionic fatty acids and/or anionic surfactants have been shown to stabilize human serum albumin (HSA) against thermal denaturation through bridging hydrophobic domains and cationic amino acids residues of the protein.

DOI10.1039/c3cc44249g
Alternate JournalJ Liposome Res