A functional common polymorphism of the ABCB1 gene is associated with chronic kidney disease and hypertension in Chinese.

TitleA functional common polymorphism of the ABCB1 gene is associated with chronic kidney disease and hypertension in Chinese.
Publication TypeJournal Article
Year of Publication2013
AuthorsLiu M, Li Y, Citterio L, Huang Q-F, Zeng W-F, Sheng C-S, Wei F-F, Dong Q, Li G-L, Kang Y-Y, Zhang L, Xu T-Y, Li J-J, Song J, Manunta P, Wang J-G
JournalAmerican journal of hypertension
Volume26
Issue12
Pagination1428-36
Date Published2013 Dec
Abstract

Permeability glycoprotein is encoded by the ATP-binding cassette B1 gene (ABCB1) and is an extruder of toxic metabolites in the kidney. A functional common polymorphism (C3435T, rs1045642) in the human ABCB1 gene has been found to be associated with allograft outcome in kidney transplant patients. In this study, we investigated the association of the C3435T polymorphism with renal function and blood pressure (BP) in 2 Chinese populations.

DOI10.2147/NDT.S47099
Alternate JournalAm. J. Hypertens.