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fMRI of intrasubject variability in ADHD: anomalous premotor activity with prefrontal compensation.
|Title||fMRI of intrasubject variability in ADHD: anomalous premotor activity with prefrontal compensation.|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Authors||Suskauer SJ, Simmonds DJ, Caffo BS, Denckla MB, Pekar JJ, Mostofsky SH|
|Journal||Journal of the American Academy of Child and Adolescent Psychiatry|
|Date Published||2008 Oct|
Children with attention-deficit/hyperactivity disorder (ADHD) consistently display increased intrasubject variability (ISV) in response time across varying tasks, signifying inefficiency of response preparation compared to typically developing (TD) children. Children with ADHD also demonstrate impaired response inhibition; inhibitory deficits correlate with ISV, suggesting that similar brain circuits may underlie both processes. To better understand the neural mechanisms underlying increased ISV and inhibitory deficits in children with ADHD, functional magnetic resonance imaging was used to examine the neural correlates of ISV during Go/No-go task performance.
|Alternate Journal||J Am Acad Child Adolesc Psychiatry|