Five new degraded diterpenoids from Trigonostemon xyphophylloides.

TitleFive new degraded diterpenoids from Trigonostemon xyphophylloides.
Publication TypeJournal Article
Year of Publication2013
AuthorsYang B, Chen G-Y, Song X-P, Yang L-Q, Wu X-Y, Han C-R, Chen W-H, Zou B-Y, Li X-M
JournalBioorganic & medicinal chemistry letters
Date Published2013 Oct 15

Five new degraded diterpenoids trigoxyphins J-N (1-5), among them trigoxyphins K and L have a novel carbon skeleton, together with four known analogues (6-9) have been obtained from the ethanol extract of the twigs of Trigonostemon xyphophylloides. Compounds 1-5 were evaluated for their cytotoxic activity in vitro against three human tumor cell lines by MTT assay. The results exhibited that Trigoxyphin N (5) showed moderate cytotoxicities against SPC-A-1 and SGC-7901 cancer cell lines.

Alternate JournalBioorg. Med. Chem. Lett.