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The first asymmetric total synthesis of (+)-coriandrone A and B.
|Title||The first asymmetric total synthesis of (+)-coriandrone A and B.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Wang W, Xue J, Tian T, Jiao Y, Li Y|
|Journal||Organic & biomolecular chemistry|
|Date Published||2013 Oct 21|
The first enantioselective total synthesis of (+)-coriandrone A and B, two bioactive natural products, has been achieved in 10 steps and 11 steps starting from commercially available methyl 2-hydroxy-4-methoxybenzoate. Key reactions include a Claison rearrangement, a Shi-type epoxidation-cyclization sequence and ortho-metallation of t-butylbenzamides with (S)-(-)-propylene oxide reaction.
|Alternate Journal||Org. Biomol. Chem.|