FFAS-3D: improving fold recognition by including optimized structural features and template re-ranking.

TitleFFAS-3D: improving fold recognition by including optimized structural features and template re-ranking.
Publication TypeJournal Article
Year of Publication2013
AuthorsXu D, Jaroszewski L, Li Z, Godzik A
JournalBioinformatics (Oxford, England)
Date Published2013 Nov 11
Abstract

 Homology detection enables grouping proteins into families and prediction of their structure and function. The range of application of homology-based predictions can be significantly extended by using sequence profiles and incorporation of local structural features. However, incorporation of the latter terms varies a lot between existing methods, and together with many examples of distant relations not recognized even by the best methods, suggests that further improvements are still possible.

DOI10.1371/journal.pone.0077095
Alternate JournalBioinformatics