Facile synthesis of tetrasaccharide aided by fluorous chemistry toward a dengue virus vaccine.

TitleFacile synthesis of tetrasaccharide aided by fluorous chemistry toward a dengue virus vaccine.
Publication TypeJournal Article
Year of Publication2013
AuthorsZhang Y, Liu B, Liu G
JournalMolecular diversity
Volume17
Issue3
Pagination613-8
Date Published2013 Aug
Abstract

We report the synthesis of a tetrasaccharide with side chain using a light-fluorous-tagged glycosyl donor through the double glycosylation and gradient fluorous solid-phase extraction by adding a little of DCM to improve the solubility for retention for the first time. This convergent method has high efficacy by saving much time and solvent.

DOI10.1124/mol.113.086140
Alternate JournalMol. Divers.