Facile synthesis of dibranched conjugated dienes via palladium-catalyzed oxidative coupling of N-tosylhydrazones.

TitleFacile synthesis of dibranched conjugated dienes via palladium-catalyzed oxidative coupling of N-tosylhydrazones.
Publication TypeJournal Article
Year of Publication2013
AuthorsJiang H, He L, Li X, Chen H, Wu W, Fu W
JournalChemical communications (Cambridge, England)
Volume49
Issue80
Pagination9218-20
Date Published2013 Oct 14
Abstract

A facile and highly regioselective Pd-catalyzed oxidative coupling of N-tosylhydrazones providing efficient access to 2,3-disubstituted-1,3-butadienes has been developed. This process features readily available starting materials and mild reaction conditions. Further transformations of the obtained dibranched 1,3-dienes, through Diels-Alder reactions and indene synthesis, are also demonstrated, which reveal their great potential for synthetic utility.

DOI10.1039/c3cc46049e
Alternate JournalChem. Commun. (Camb.)