Fabrication of red-blood-cell-like polyelectrolyte microcapsules and their deformation and recovery behavior through a microcapillary.

TitleFabrication of red-blood-cell-like polyelectrolyte microcapsules and their deformation and recovery behavior through a microcapillary.
Publication TypeJournal Article
Year of Publication2013
AuthorsShe S, Li Q, Shan B, Tong W, Gao C
JournalAdvanced materials (Deerfield Beach, Fla.)
Volume25
Issue40
Pagination5814-8
Date Published2013 Oct 25
Abstract

Multilayer microcapsules with a biconcave discoidal shape mimicking red blood cells (RBCs) are fabricated. The structure of the RBC-like microcapsules is verified by scanning electron and confocal laser scanning microscopies. The capsules show elastic deformation after being forced through a microcapillary with a smaller diameter, exhibiting a high recovery ratio of ≈90%. When the capsules are coated with hemoglobin (Hb),they are able to reversibly bind and release oxygen.

DOI10.1093/cid/cit540
Alternate JournalAdv. Mater. Weinheim