News & Updates
Search Research Content
Resource Finder at Kennedy Krieger Institute
A free resource that provides access to information and support for individuals and families living with developmental disabilities.
Extensive telomere erosion in the initiation of colorectal adenomas and its association with chromosomal instability.
|Title||Extensive telomere erosion in the initiation of colorectal adenomas and its association with chromosomal instability.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Roger L, Jones RE, Heppel NH, Williams GT, Sampson JR, Baird DM|
|Journal||Journal of the National Cancer Institute|
|Date Published||2013 Aug 21|
Telomere shortening, dysfunction, and fusion may facilitate the acquisition of large-scale genomic rearrangements, driving clonal evolution and tumor progression. The relative contribution that telomere dysfunction and/or APC mutation play in the chromosome instability that occurs during colorectal tumorigenesis is not clear.
|Alternate Journal||J. Natl. Cancer Inst.|