Extensive telomere erosion in the initiation of colorectal adenomas and its association with chromosomal instability.

TitleExtensive telomere erosion in the initiation of colorectal adenomas and its association with chromosomal instability.
Publication TypeJournal Article
Year of Publication2013
AuthorsRoger L, Jones RE, Heppel NH, Williams GT, Sampson JR, Baird DM
JournalJournal of the National Cancer Institute
Volume105
Issue16
Pagination1202-11
Date Published2013 Aug 21
Abstract

Telomere shortening, dysfunction, and fusion may facilitate the acquisition of large-scale genomic rearrangements, driving clonal evolution and tumor progression. The relative contribution that telomere dysfunction and/or APC mutation play in the chromosome instability that occurs during colorectal tumorigenesis is not clear.

DOI10.1093/jxb/ert178
Alternate JournalJ. Natl. Cancer Inst.