An extensive epidemiological investigation of a kidney cancer cluster in a chemical plant: what have we learned?

TitleAn extensive epidemiological investigation of a kidney cancer cluster in a chemical plant: what have we learned?
Publication TypeJournal Article
Year of Publication2014
AuthorsIwatsubo Y, Bénézet L, Boutou-Kempf O, Févotte J, Garras L, Goldberg M, Luce D, Pilorget C, Imbernon E
JournalOccupational and environmental medicine
Volume71
Issue1
Pagination4-11
Date Published2014 Jan
Abstract

In 2003, a cluster of renal cell carcinoma (RCC) cases was reported among men working at a French chemical plant using a proprietary process to produce vitamin A. The 10 index cases yielded a standardised incidence ratio of 13.1 for 1994-2002. Nine of these 10 cases were diagnosed by a plant-specific abdominal ultrasonography screening programme that targeted exposure to an intermediate chemical, 4-chloro-1,1-dimethoxy-3-methyl-2-butene, commonly named 'chloracetal C5', suspected as the cause by some experts. Epidemiological investigations sought to examine the relations between occupational exposures and RCC.

DOI10.1073/pnas.1314380110
Alternate JournalOccup Environ Med