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[Expression of PD-L1 in lymphoma and its effect on lymphoma proliferation and chemotherapy resistance].
|Title||[Expression of PD-L1 in lymphoma and its effect on lymphoma proliferation and chemotherapy resistance].|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Li Y, Wang J, Ke X-Y|
|Journal||Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology|
|Date Published||2013 Apr|
In order to investigate the effect of PD-L1 on lymphoma cell proliferation and chemotherapy resistance, and explore a new and promising approach for therapy of lymphomas. The level of PD-L1 expression in tissues of patients with lymphoma and cell lines were detected by immunohistochemistry and flow cytometry. Both the stable high-PDL1-A20 cell strain and low-PDL1-A20 cell strain were sorted by flow cytometry, then inoculated into BALB/c mice as to establish a lymphoma bearing mouse model for observing tumor genesis. Finally, the effect of PD-L1 on routinely chemotherapy drug-cisplatin were observed. The results showed that the PD-L1 highly and widely expressed in lymphoma tissue and cell strains, the stable high-PD-L1 cell strain sorted by flow cytometry have higher lymphoma genesis than that of low-PD-L1 cell strain. It is concluded that PD-L1 can promote lymphoma genesis, meanwhile the PD-L1 may resist effect of cisplatin on lymphoma cells through anti-apoptosis.
|Alternate Journal||Zhongguo Shi Yan Xue Ye Xue Za Zhi|