Expression and clinical significance of the nin one binding protein and p38 MAPK in prostate carcinoma.

TitleExpression and clinical significance of the nin one binding protein and p38 MAPK in prostate carcinoma.
Publication TypeJournal Article
Year of Publication2013
AuthorsChe J-P, Li W, Yan Y, Liu M, Wang G-C, Li Q-Y, Yang B, Yao X-D, Zheng J-H
JournalInternational journal of clinical and experimental pathology
Volume6
Issue11
Pagination2300-11
Date Published2013
Abstract

Prostate carcinoma is a major cause of morbidity and mortality. The MAPK Signaling Pathway plays an important role in multiple tumors, including prostate carcinoma. MAPK signaling is mediated by ERK1/2, JNK and p38 MAPK, which are important in the control of cell proliferation, differentiation and apoptosis. However, relatively little is known about the regulatory mechanism of p38 MAPK in prostate cancers. NOB1 is among the most novel topic in MAPK studies currently. Recent studies found its vital role in tumor metastasis in glioblastoma proliferation, however, its expression profile and its prognostic value in prostate carcinoma have not been investigated.

DOI10.4103/2156-7514.119019
Alternate JournalInt J Clin Exp Pathol