Estrogen receptor α regulates ATM Expression through miRNAs in breast cancer.

TitleEstrogen receptor α regulates ATM Expression through miRNAs in breast cancer.
Publication TypeJournal Article
Year of Publication2013
AuthorsGuo X, Yang C, Qian X, Lei T, Li Y, Shen H, Fu L, Xu B
JournalClinical cancer research : an official journal of the American Association for Cancer Research
Volume19
Issue18
Pagination4994-5002
Date Published2013 Sep 15
Abstract

Estrogen receptor α (ERα) is an essential element regulating mammary gland development and it contributes to breast cancer development and progression. Most of the ER-negative breast cancers display more aggressive clinical behaviors and are resistant to antiestrogen therapies. In addition, many ER-negative tumors show insensitivity to many chemotherapeutic drugs and radiotherapy, although mechanisms underlying this phenotype are less clear.

DOI10.1088/0957-4484/24/31/315203
Alternate JournalClin. Cancer Res.