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Epidermal growth factor receptor-containing exosomes induce tumor-specific regulatory T cells.
|Title||Epidermal growth factor receptor-containing exosomes induce tumor-specific regulatory T cells.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Huang S-H, Li Y, Zhang J, Rong J, Ye S|
|Date Published||2013 Jun|
The epidermal growth factor receptor (EGFR) has a close relation to lung cancer; its role in the pathogenesis of lung cancer is to be further elucidated. The results of this study indicate that about 80% exosomes purified from the LC biopsies contained EGFR; only about 2% exosomes contained EGFR in the samples from chronic lung inflammation. The purified exosomes induced tolerogenic DCs. Coculture of the tolerogenic DCs and Th0 cells generated the tumor antigen-specific regulatory T cells (Treg). The Tregs could suppress the tumor antigen specific CD8+ T cells.
|Alternate Journal||Cancer Invest.|