Elevated arteriolar cerebral blood volume in prodromal Huntington's disease.

TitleElevated arteriolar cerebral blood volume in prodromal Huntington's disease.
Publication TypeJournal Article
Year of Publication2013
AuthorsHua J, Unschuld PG, Margolis RL, van Zijl PCM, Ross CA
JournalMovement disorders : official journal of the Movement Disorder Society
Date Published2013 Jul 11
Abstract

Neurovascular alterations have been implicated in the pathophysiology of Huntington's disease (HD). Because arterioles are most responsive to metabolic alterations, arteriolar cerebral blood volume (CBVa ) is an important indicator of cerebrovascular regulation. The objective of this pilot study was to investigate potential neurovascular (CBVa ) abnormality in prodromal-HD patients and compare it with the widely used imaging marker: brain atrophy.

DOI10.1155/2013/859763
Alternate JournalMov. Disord.