Efficient access to 1,4-benzothiazine: palladium-catalyzed double C-S bond formation using Na2S2O3 as sulfurating reagent.

TitleEfficient access to 1,4-benzothiazine: palladium-catalyzed double C-S bond formation using Na2S2O3 as sulfurating reagent.
Publication TypeJournal Article
Year of Publication2013
AuthorsQiao Z, Liu H, Xiao X, Fu Y, Wei J, Li Y, Jiang X
JournalOrganic letters
Volume15
Issue11
Pagination2594-7
Date Published2013 Jun 7
Abstract

A novel Pd-catalyzed double C-S bond formation coupling reaction has been developed. This protocol, in which Na2S2O3 was used as sulfurating reagent in metal-catalyzed reactions, provides an efficient method for the synthesis of substituted 1,4-benzothiazine derivates, which are structural elements of numerous bioactivity molecules rendering this protocol attractive to both synthetic and medicinal chemistry.

DOI10.1155/2013/915213
Alternate JournalOrg. Lett.