Effects of external stimuli on the pacemaker function of the sinoatrial node in sodium channel gene mutations models.

TitleEffects of external stimuli on the pacemaker function of the sinoatrial node in sodium channel gene mutations models.
Publication TypeJournal Article
Year of Publication2013
AuthorsZhang J, Li X, Liang L, Huang S, Zhang H
JournalScience China. Life sciences
Volume56
Issue9
Pagination818-22
Date Published2013 Sep
Abstract

Loss of function and gain of function mutations of the sodium channel were investigated using an intact two-dimensional rabbit sinoatrial node (SAN) and atrial cell model. The effects of three external stimuli (acetylcholine secretion by the vagal nerve, acid-base concentration, and tissue temperature) on cardiac pacemaker function and conduction were studied. Our results show that these two groups of mutations have different effects on pacemaker function and conduction. Furthermore, we found that the negative effects of these mutations could be altered by external stimuli. The bradycardic effects of mutations were magnified by an increase in acetylcholine level. Changes in acid-base concentration and tissue temperature increased the ability of the SAN to recover its pacemaker function. The results of this study increase our understanding of sodium channel disorders, and help to advance research on the treatment of these conditions.

DOI10.1002/hep.26667
Alternate JournalSci China Life Sci