Effects of CYP2C19 loss-of-function variants on the eradication of H. pylori infection in patients treated with proton pump inhibitor-based triple therapy regimens: a meta-analysis of randomized clinical trials.

TitleEffects of CYP2C19 loss-of-function variants on the eradication of H. pylori infection in patients treated with proton pump inhibitor-based triple therapy regimens: a meta-analysis of randomized clinical trials.
Publication TypeJournal Article
Year of Publication2013
AuthorsTang H-L, Li Y, Hu Y-F, Xie H-G, Zhai S-D
JournalPloS one
Volume8
Issue4
Paginatione62162
Date Published2013
Abstract

There are inconsistent conclusions about whether CYP2C19 variants could affect H. pylori eradication rate in patients treated with the proton pump inhibitor (PPI)-based therapy. We therefore performed a meta-analysis of randomized clinical trials (RCTs) to re-evaluate the impact of CYP2C19 variants on PPI-based triple therapy for the above indication.

DOI10.1371/journal.pone.0062162
Alternate JournalPLoS ONE