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The effect of lansoprazole, an OCT inhibitor, on metformin pharmacokinetics in healthy subjects.
|Title||The effect of lansoprazole, an OCT inhibitor, on metformin pharmacokinetics in healthy subjects.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Ding Y, Jia Y, Song Y, Lu C, Li Y, Chen M, Wang M, Wen A|
|Journal||European journal of clinical pharmacology|
|Date Published||2013 Oct 30|
Gastro-esophageal reflux disease is common in patients with type 2 diabetes. A common treatment is the co-administration of proton-pump inhibitors (PPIs) and metformin. To date, however, the effects of co-administration of PPIs, which inhibit organic cation transporter (OCT) activity, on the action of metformin (a well-known substrate of OCTs) have not been clearly demonstrated.
|Alternate Journal||Eur. J. Clin. Pharmacol.|