The effect of lansoprazole, an OCT inhibitor, on metformin pharmacokinetics in healthy subjects.

TitleThe effect of lansoprazole, an OCT inhibitor, on metformin pharmacokinetics in healthy subjects.
Publication TypeJournal Article
Year of Publication2013
AuthorsDing Y, Jia Y, Song Y, Lu C, Li Y, Chen M, Wang M, Wen A
JournalEuropean journal of clinical pharmacology
Date Published2013 Oct 30
Abstract

Gastro-esophageal reflux disease is common in patients with type 2 diabetes. A common treatment is the co-administration of proton-pump inhibitors (PPIs) and metformin. To date, however, the effects of co-administration of PPIs, which inhibit organic cation transporter (OCT) activity, on the action of metformin (a well-known substrate of OCTs) have not been clearly demonstrated.

DOI10.2337/dc13-1142
Alternate JournalEur. J. Clin. Pharmacol.