News & Updates
Search Research Content
Resource Finder at Kennedy Krieger Institute
A free resource that provides access to information and support for individuals and families living with developmental disabilities.
The effect of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats.
|Title||The effect of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Xu J-S, Li Y, Cao X, Cui Y|
|Journal||Experimental and therapeutic medicine|
|Date Published||2013 Jun|
Eugenol has been widely used in medicine due to its antibacterial, anti-inflammatory, antioxidant, anticancer and analgesic properties. The present study was designed to investigate the effects of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats. Eugenol demonstrated significant inhibitory effects against acid production by S. mutans. The synthesis of water-insoluble glucans by glucosyltransferases was reduced by eugenol. Eugenol also markedly suppressed the adherence of S. mutans to saliva-coated hydroxyapatite beads. Furthermore, topical application of eugenol reduced the incidence and severity of carious lesions in rats. These results suggest that the natural compound eugenol may be a useful therapeutic agent for dental caries.
|Alternate Journal||Exp Ther Med|