The effect of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats.

TitleThe effect of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats.
Publication TypeJournal Article
Year of Publication2013
AuthorsXu J-S, Li Y, Cao X, Cui Y
JournalExperimental and therapeutic medicine
Volume5
Issue6
Pagination1667-1670
Date Published2013 Jun
Abstract

Eugenol has been widely used in medicine due to its antibacterial, anti-inflammatory, antioxidant, anticancer and analgesic properties. The present study was designed to investigate the effects of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats. Eugenol demonstrated significant inhibitory effects against acid production by S. mutans. The synthesis of water-insoluble glucans by glucosyltransferases was reduced by eugenol. Eugenol also markedly suppressed the adherence of S. mutans to saliva-coated hydroxyapatite beads. Furthermore, topical application of eugenol reduced the incidence and severity of carious lesions in rats. These results suggest that the natural compound eugenol may be a useful therapeutic agent for dental caries.

DOI10.1007/s00586-013-2886-2
Alternate JournalExp Ther Med