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Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia.
|Title||Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia.|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Authors||Walczak P, Zhang J, Gilad AA, Kedziorek DA, Ruiz-Cabello J, Young RG, Pittenger MF, van Zijl PCM, Huang J, Bulte JWM|
|Journal||Stroke; a journal of cerebral circulation|
|Date Published||2008 May|
In animal models of stroke, functional improvement has been obtained after stem cell transplantation. Successful therapy depends largely on achieving a robust and targeted cell engraftment, with intraarterial (IA) injection being a potentially attractive route of administration. We assessed the suitability of laser Doppler flow (LDF) signal measurements and magnetic resonance (MR) imaging for noninvasive dual monitoring of targeted IA cell delivery.