A dual DTI approach to analyzing white matter in children with dyslexia.

TitleA dual DTI approach to analyzing white matter in children with dyslexia.
Publication TypeJournal Article
Year of Publication2009
AuthorsCarter JC, Lanham DC, Cutting LE, Clements-Stephens AM, Chen X, Hadzipasic M, Kim J, Denckla MB, Kaufmann WE
JournalPsychiatry research
Volume172
Issue3
Pagination215-9
Date Published2009 Jun 30
Abstract

Using voxel-based (VBA) and region-of-interest (ROI) diffusion tensor imaging (DTI) analyses, we examined white matter (WM) organization in seven children with dyslexia and six age-matched controls. Both methods demonstrated reduced fractional anisotropy (FA) in the left superior longitudinal fasciculus (SLF) and abnormal orientation in the right SLF in dyslexics. Application of this complementary dual DTI approach to dyslexia, which included novel analyses of fiber orientation, demonstrates its usefulness for analyzing mild and complex WM abnormalities.

DOI10.1177/0883073808329529
Alternate JournalPsychiatry Res