Doxorubicin caused apoptosis of mesenchymal stem cells via p38, JNK and p53 pathway.

TitleDoxorubicin caused apoptosis of mesenchymal stem cells via p38, JNK and p53 pathway.
Publication TypeJournal Article
Year of Publication2013
AuthorsYang F, Chen H, Liu Y, Yin K, Wang Y, Li X, Wang G, Wang S, Tan X, Xu C, Lu Y, Cai B
JournalCellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Volume32
Issue4
Pagination1072-82
Date Published2013
Abstract

Doxorubicin is a widely used chemotherapeutic agent, but its clinical use is restricted because of a high risk of cardiotoxicity. Bone marrow-derived mesenchymal stem cells (BMSCs) may repair ischaemically damaged myocardium through transdifferentiation and paracrine action. The aim of this study is to investigate if doxorubicin causes the apoptosis of BMSCs and in turn impairs its healing ability.

DOI10.1371/journal.pone.0080011
Alternate JournalCell. Physiol. Biochem.