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Doxorubicin caused apoptosis of mesenchymal stem cells via p38, JNK and p53 pathway.
|Title||Doxorubicin caused apoptosis of mesenchymal stem cells via p38, JNK and p53 pathway.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Yang F, Chen H, Liu Y, Yin K, Wang Y, Li X, Wang G, Wang S, Tan X, Xu C, Lu Y, Cai B|
|Journal||Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology|
Doxorubicin is a widely used chemotherapeutic agent, but its clinical use is restricted because of a high risk of cardiotoxicity. Bone marrow-derived mesenchymal stem cells (BMSCs) may repair ischaemically damaged myocardium through transdifferentiation and paracrine action. The aim of this study is to investigate if doxorubicin causes the apoptosis of BMSCs and in turn impairs its healing ability.
|Alternate Journal||Cell. Physiol. Biochem.|