Diterpenoids from the twigs and leaves of Fokienia hodginsii.

TitleDiterpenoids from the twigs and leaves of Fokienia hodginsii.
Publication TypeJournal Article
Year of Publication2013
AuthorsWu X-D, He J, Li X-Y, Dong L-B, Gong X, Song L-D, Li Y, Peng L-Y, Zhao Q-S
JournalJournal of natural products
Volume76
Issue6
Pagination1032-8
Date Published2013 Jun 28
Abstract

Five new isopimarane diterpenoids, fokihodgins A-E (1-5), four new labdane diterpenoids, fokihodgins F-I (6-9), and one new icetexane diterpenoid, fokihodgin J (10), as well as 18 known diterpenoids were isolated from Fokienia hodginsii. The structures of the new compounds were determined on the basis of their spectroscopic analysis, and the absolute configurations of 1 and 6 were established by X-ray crystallographic analysis. Compound 9 showed moderate cytotoxicity against HL-60 and SMMC-7721 cell lines, with IC50 values of 9.10 and 7.50 μM, respectively.

DOI10.1371/journal.pone.0076782
Alternate JournalJ. Nat. Prod.