Diffusion tensor imaging of periventricular leukomalacia shows affected sensory cortex white matter pathways.

TitleDiffusion tensor imaging of periventricular leukomalacia shows affected sensory cortex white matter pathways.
Publication TypeJournal Article
Year of Publication2002
AuthorsHoon AH, Lawrie WT, Melhem ER, Reinhardt EM, van Zijl PCM, Solaiyappan M, Jiang H, Johnston MV, Mori S
JournalNeurology
Volume59
Issue5
Pagination752-6
Date Published2002 Sep 10
Abstract

The authors used diffusion-tensor imaging to examine central white matter pathways in two children with spastic quadriplegic cerebral palsy. Corticospinal tracts projecting from cortex to brainstem resembled controls. In contrast, posterior regions of the corpus callosum, internal capsule, and corona radiata were markedly reduced, primarily in white matter fibers connected to sensory cortex. These findings suggest that the motor impairment in periventricular leukomalacia may, in part, reflect disruption of sensory connections outside classic pyramidal motor pathways.

Alternate JournalNeurology