Diffusion tensor imaging in children with periventricular leukomalacia: variability of injuries to white matter tracts.

TitleDiffusion tensor imaging in children with periventricular leukomalacia: variability of injuries to white matter tracts.
Publication TypeJournal Article
Year of Publication2007
AuthorsNagae LM, Hoon AH, Stashinko E, Lin D, Zhang W, Levey E, Wakana S, Jiang H, Leite CC, Lucato LT, van Zijl PCM, Johnston MV, Mori S
JournalAJNR. American journal of neuroradiology
Volume28
Issue7
Pagination1213-22
Date Published2007 Aug
Abstract

Conventional MR imaging shows evidence of brain injury and/or maldevelopment in 70%-90% of children with cerebral palsy (CP), though its capability to identify specific white matter tract injury is limited. The great variability of white matter lesions in CP already demonstrated by postmortem studies is thought to be one of the reasons why response to treatment is so variable. Our hypothesis is that diffusion tensor imaging (DTI) is a suitable technique to provide in vivo characterization of specific white matter tract lesions in children with CP associated with periventricular leukomalacia (PVL).

DOI10.1021/jo800879e
Alternate JournalAJNR Am J Neuroradiol