Diffusion tensor imaging in children and adolescents: reproducibility, hemispheric, and age-related differences.

TitleDiffusion tensor imaging in children and adolescents: reproducibility, hemispheric, and age-related differences.
Publication TypeJournal Article
Year of Publication2007
AuthorsBonekamp D, Nagae LM, Degaonkar M, Matson M, Abdalla WMA, Barker PB, Mori S, Horská A
JournalNeuroImage
Volume34
Issue2
Pagination733-42
Date Published2007 Jan 15
Abstract

We evaluated intra-rater, inter-rater, and between-scan reproducibility, hemispheric differences, and the effect of age on apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in healthy children (age range 5.5-19.1 years) examined with a clinical diffusion tensor imaging (DTI) protocol at 1.5 T, using a region of interest (ROI) methodology. Measures of reliability and precision were assessed in six ROIs using two different ROI shapes (polygonal and ellipsoidal). Results: Highly reproducible values of ADC and FA were obtained with the polygonal method on intra-rater (coefficients of variation

DOI10.1371/journal.pone.0064024
Alternate JournalNeuroimage