Dexamethasone Down-Regulates the Expression of microRNA-155 in the Livers of Septic Mice.

TitleDexamethasone Down-Regulates the Expression of microRNA-155 in the Livers of Septic Mice.
Publication TypeJournal Article
Year of Publication2013
AuthorsWang Z-H, Liang Y-B, Tang H, Chen Z-B, Li Z-Y, Hu X-C, Ma Z-F
JournalPloS one
Volume8
Issue11
Paginatione80547
Date Published2013
Abstract

To investigate the expression of microRNA-155 (miRNA-155) in the livers of mice with lipopolysaccharide (LPS)-induced sepsis and to determine the role of dexamethasone (DXM) in the regulation of miRNA-155 expression, we pretreated mice with or without DXM prior to LPS exposure. Our study demonstrated that the expression of miRNA-155 and inflammatory factors increased in the liver tissues of mice with LPS-induced sepsis and that DXM down-regulated their expression in a dose-dependent manner. Moreover, DXM alone inhibited the expression of miRNA-155 to below the baseline level, but did not impact the expression of inflammatory factors, suggesting that the down-regulation of miRNA-155 by DXM may partially, but not completely, depend on the suppression of pro-inflammatory cytokines by DXM. Our data indicate that the overexpression of miRNA-155 in the livers of mice with LPS-induced sepsis may play an important role in the pathological processes of sepsis and that the down-regulation of miRNA-155 by DXM may be a novel mechanism regulating inflammation and immunity.

DOI10.1371/journal.pone.0080605
Alternate JournalPLoS ONE