Determination of oxygen extraction ratios by magnetic resonance imaging.

TitleDetermination of oxygen extraction ratios by magnetic resonance imaging.
Publication TypeJournal Article
Year of Publication1999
AuthorsOja JM, Gillen JS, Kauppinen RA, Kraut M, van Zijl PC
JournalJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Volume19
Issue12
Pagination1289-95
Date Published1999 Dec
Abstract

The oxygen extraction ratio (OER) of a tissue describes the interplay between oxygen delivery and consumption and, as such, directly reflects the viability and activity of any organ. It is shown that OER can be quantified using a single magnetic resonance imaging observable, namely the relaxation time T2 of venous blood draining from the tissue. This principle is applied to study local OER changes in the brain on visual stimulation in humans, unambiguously demonstrating a mismatch between changes in blood flow and oxygen metabolism on activation.

Alternate JournalJ. Cereb. Blood Flow Metab.